Toxic epidermal necrosis - Giftige Epidermale Nekrose
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Karakteristyk hûdferlies fan Giftige Epidermale Nekrose (Toxic epidermal necrosis)
References
Stevens-Johnson Syndrome (SJS) en Toxic Epidermal Necrolysis (TEN) binne seldsume betingsten wêrby't de hûd wiidweidige nekrose en ferlies ûnderfynt. Yn termen fan behanneling is cyclosporine tige effektyf foar SJS, wylst in kombinaasje fan intravenous immunoglobulin (IVIg) en corticosteroids it bêste wurket foar gefallen fan SJS en TEN.
Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare diseases that are characterized by widespread epidermal necrosis and sloughing of skin. Regarding treatment, cyclosporine is the most effective therapy for the treatment of SJS, and a combination of intravenous immunoglobulin (IVIg) and corticosteroids is most effective for SJS/TEN overlap and TEN.
Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare diseases that are characterized by widespread epidermal necrosis and sloughing of skin. Regarding treatment, cyclosporine is the most effective therapy for the treatment of SJS, and a combination of intravenous immunoglobulin (IVIg) and corticosteroids is most effective for SJS/TEN overlap and TEN.
Toxic epidermal necrolysis (TEN) is in serieuze hûdreaksje feroarsake troch bepaalde medisinen en aktiviteit fan it ymmúnsysteem, wat resulteart yn grutskalige losmeitsjen fan 'e bûtenste hûdlaach (epidermis) , dy't mear as 30% fan it lichemsoerflak beynfloedet. TEN hat in mortaliteit fan mear as 20%, faak troch ynfeksjes en sykheljen swierrichheden. It stopjen fan de medikaasje dy't de reaksje feroarsake, stypjende soarch en it brûken fan ekstra behannelingen kin it resultaat ferbetterje. Resinte stúdzjes hawwe sjen litten dat medisinen lykas cyclosporine, tumor nekrose faktor alfa-ynhibitoren, en in kombinaasje fan yntravenous ymmúnglobuline en kortikosteroïden nuttich kinne wêze, basearre op randomisearre kontroleare proeven en analyzes fan meardere stúdzjes.
Toxic epidermal necrolysis (TEN) is a serious skin reaction caused by certain medications and immune system activity, resulting in large-scale detachment of the outer skin layer (epidermis), affecting more than 30% of the body's surface. TEN has a mortality rate of over 20%, often due to infections and breathing difficulties. Stopping the medication causing the reaction, providing supportive care, and using additional treatments can improve the outcome. Recent studies have shown that drugs like cyclosporine, tumor necrosis factor alpha inhibitors, and a combination of intravenous immune globulin and corticosteroids can be helpful, based on randomized controlled trials and analyses of multiple studies.
Toxic epidermal necrolysis (TEN) is a serious skin reaction caused by certain medications and immune system activity, resulting in large-scale detachment of the outer skin layer (epidermis), affecting more than 30% of the body's surface. TEN has a mortality rate of over 20%, often due to infections and breathing difficulties. Stopping the medication causing the reaction, providing supportive care, and using additional treatments can improve the outcome. Recent studies have shown that drugs like cyclosporine, tumor necrosis factor alpha inhibitors, and a combination of intravenous immune globulin and corticosteroids can be helpful, based on randomized controlled trials and analyses of multiple studies.
Recent Advances: There is improved understanding of pain and morbidity with regard to the type and frequency of dressing changes. More modern dressings, such as nanocrystalline, are currently favored as they may be kept in situ for longer periods. The most recent evidence on systemic agents, such as corticosteroids and cyclosporine, and novel treatments, are also discussed.
De meast foarkommende oarsaak is bepaalde medisinen lykas lamotrigine, carbamazepine, allopurinol, sulfonamide antibiotika, en nevirapine. Risikofaktoaren omfetsje HIV en systemyske lupus erythematosus. Behanneling fynt typysk plak yn it sikehûs lykas yn in burn-ienheid of intensive care-ienheid.
○ Behanneling
Dit is in serieuze sykte, dus as jo lippen of mûle binne beynfloede of jo hûd wurdt blistered, sjoch jo dokter sa gau mooglik.
Fertochte medisinen moatte stopset wurde. (bgl. antibiotika, net-steroidale anty-inflammatoare medisinen)